Cryoglobulinemia pictures

Pictures of Cryoglobulinemia vasculitis affects provided by CVO patients, CVO is a rare blood disease Cryoglobulinemia is a rare disease that develops as a result of the presence of high levels of abnormal proteins, called cryoglobulins, in the blood. In cold temperatures, these proteins clump together and block blood vessels, potentially causing a wide range of complications. There are several types of cryoglobulinemia that are classified. The distinction between type II and type III cryoglobulinemia is mostly technical and deals with whether the rheumatoid factor is monoclonal or polyclonal. The clinical pictures of type II and III cryoglobulinemia are similar. The type of cryoglobulinemia found in patients is roughly 25% with type I, 25% with type II and 50% with type III

Cryoglobulinemia Pictures - dianedike

  1. Cryoglobulinemia can damage the nerves at the tips of your fingers and toes, causing numbness and other problems. Causes. Cryoglobulinemia has been associated with: Infections. Hepatitis C is the most common infection associated with cryoglobulinemia. Others include hepatitis B, HIV, Epstein-Barr, toxoplasmosis and malaria
  2. 13 Cryoglobulinemia Pictures; It is a condition that is characterized by the presence of large amounts of abnormal proteins in the bloodstream that turn gel-like or thick in cold temperatures. These proteins are known as Cryoglobulins. The term Cryoglobulinemia actually refers to the presence in serum of these immunoglobulins that.
  3. The clinical pictures of type II and III cryoglobulinemia are similar. This report primarily deals with mixed cryoglobulinemia. Signs & Symptoms. The symptoms and physical findings of mixed cryoglobulinemia can vary greatly from one individual to another. Many different organ symptoms can be potentially become involved
  4. Cryoglobulinaemia is a rare disorder characterised by the presence of abnormal immunoglobulin proteins in the blood that can precipitate out into tissues at low temperatures and causing inflammation and damage. Immunoglobulins are the class of proteins that make antibodies in response to foreign substances ( antigens) introduced into the body
  5. e its cause. It takes almost a week after the test is ordered to get the result

What is Cryoglobulinemia? (with pictures

Cryoglobulinemia is a form of vasculitis—a family of rare disorders characterized by inflammation of the blood vessels, which can restrict blood flow and damage vital organs and tissues. In cryoglobulinemia, abnormal blood proteins called cryoglobulins clump together at cold temperatures, restricting blood flow and causing damage to skin. Classification of cryoglobulinemia is based on a system developed more than 40 years ago. It has the advantage of correlating with pathogenicity and clinical manifestations, which differ among types. 3 In type I cryoglobulinemia, the cryoglobulins are monoclonal immunoglobulins (Ig's), usually of the IgG or IgM isotypes and rarely IgA or free immunoglobulin light chains. 4 Type I.

Cryoglobulinemic vasculitis occurs when the body makes a mix of abnormal immune system proteins called cryoglobulins. At temperatures less than 98.6 degrees Fahrenheit (normal body temperature), cryoglobulins become solid or gel-like and can block blood vessels. This causes a variety of health problems. Many people with cryoglobulins will not. Flickr photos, groups, and tags related to the cryoglobulinemia Flickr tag Cryoglobulinemia is a condition that results when a person lacks a protein in the blood called cryoglobulin. It can result from an infection, a connective tissue disease, some cancers, and other.

Cryoglobulinemia means cold antibody in the blood and is the presence of abnormal antibodies that are soluble in the blood at body temperature but which precipitate out of the blood at lower temperatures in the laboratory. These antibodies are often present in patients with a wide variety of pre-existing diseases such as hepatitis C virus. The management of cryoglobulinemia especially in patients with organ damage remains difficult. Treatment of cryoglobulinemia focuses on management of the underlying lymphoproliferative disorder or infectious or systemic causes. Medical management may also include corticosteroids and other immunosuppressive agents and plasmapheresis Simple cryoglobulinemia occurs when the body makes an abnormal immune system protein called a cryoglobulin. At temperatures less than 98.6 degrees Fahrenheit (normal body temperature), cryoglobulins become solid or gel-like and can block blood vessels. This causes a variety of health problems. Many people with cryoglobulins will not experience.

The clinical presentation of mixed cryoglobulinemia is quite variable. Cutaneous leukocytoclastic vasculitis is the most clinically evident manifestation. It usually presents with palpable purpura and petechiae that involve the lower extremities.8 Skin lesions are not always obvious and are sometimes not present Cryoglobulinemia. The name literally means cold antibody in the blood, which refers to the chemical properties of the antibodies that cause this disease: cryoglobulins are antibodies that precipitate under cold conditions. Drug use is a prime risk factor for cryoglobulinemia because more than 90% of cases of cryoglobulinemic vasculitis.

Cryoglobulinemia - Causes, Types, Symptoms, Diagnosis

Cohen SJ, Pittelkow MR, Su WP. Cutaneous manifestations of cryoglobulinemia: clinical and histopathologic study of seventy-two patients. J Am Acad Dermatol 1991; 25:21. Giuggioli D, Manfredi A, Lumetti F, et al. Cryoglobulinemic vasculitis and skin ulcers. Our therapeutic strategy and review of the literature. Semin Arthritis Rheum 2015; 44:518 Cutaneous manifestations. These manifestations are nearly always present in cryoglobulinemia. Observed lesions have a predilection for dependent areas (particularly the lower extremities) and include erythematous macules and purpuric papules (90-95%), as well as ulcerations (10-25%) Cryoglobulinemia associated with a particular disease (lymphoproliferative disorder, autoimmune disease, infectious disease) is known as secondary cryoglobulinemia. In a French study of 36 patients with type I cryoglobulinemia, skin or vasomotor symptoms were present in 75%; nephropathy in 30%; and neuropathy in 47% General signs and symptoms of most types of vasculitis include: Fever. Headache. Fatigue. Weight loss. General aches and pains. Other signs and symptoms are related to the parts of the body affected, including: Digestive system. If your stomach or intestines are affected, you may experience pain after eating

Cryoglobulinemia - Symptoms and causes - Mayo Clini

Cryoglobulinemia - Prime Health Channe

Cryoglobulinemia is rare, with an estimate of fewer than 5 cases per 10 000 individuals in Europe and North America. It is more common in Southern Europe than in Northern Europe or North America. The time course is most often chronic but varies depending on the underlying condition and response to treatment. Overall survival in HCV-associated. Blood disorders (cryoglobulinemia, polycythemia) Thyroid problems; 7 / 16 Symptoms. An attack usually hits the fingers and toes, but can also strike your nose, ears, nipples, or lips. It. Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins. Several types of cryoglobulins have been identified, and the potential clinical manifestations vary by cryoglobulin type. The presence of cryoglobulins in the serum may result in a clinical syndrome of systemic inflammation (most commonly. Hepatitis C is also commonly implicated to the onset leukocytoclastic vasculitis especially with the presence of cryoglobulinemia; There are some diseases that are being associated with leukocytoclastic vasculitis such as: Crohn's disease. Crohn's disease is an inflammatory bowel disease associated with the onset of leukocytoclastic vasculitis Vasculitis can also cause Behcet's syndrome (eye inflammation, acne and genital ulcers), Buerger's disease (inflammation of extremities and ulcers on fingers/toes), Churg Strauss syndrome (inflammation of lungs) and condition called cryoglobulinemia (affecting hands/toes causing nerve damage)

Mixed Cryoglobulinemia - NORD (National Organization for

Cryoglobulinaemia DermNet N

Mixed cryoglobulinemia is characterized by rheumatoid factor activity with a mixture of monoclonal or polyclonal immunoglobulins. It results from immune complex deposition in cold temperatures, which is commonly associated with hepatitis C and autoimmune diseases Livedoid vasculopathy is a clinical diagnosis, supported by skin biopsy of a red papule or the edge of a new ulcer. Histopathology reveals hyalinisation, thickened blood vessel walls, fibrin deposition, vascular occlusion by thrombosis and minimal inflammation. Direct immunofluorescence often shows deposition of immunoglobulin and complement. Porphyria cutanea tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. Liver abnormalities may also occur Cryoglobulinemia is a medical condition that is caused by proteins in the blood called cryoglobulins. Cryoglobulins are abnormal proteins that by definition have the property of precipitating from the serum when it is chilled in the laboratory and then dissolving back into the serum upon rewarming

Cryoglobulinemia is caused by an abnormal protein that is occasionally found in the blood of people with multiple myeloma, leukemia, and certain forms of pneumonia. It causes blood to gel at low temperatures. In this picture, cryoglobulinemia has reduced blood flow in the fingers so much the fingers have turned dark In the early stages, many people only experience skin symptoms, which may include redness, rashes, and smaller patches. But if these skin symptoms progress, larger areas of the skin will be affected with more intense redness, scaling, and lesions. In some people, CTCL can spread to other parts of the body such as the blood and lymph nodes

Cryoglobulinemia | Healthing

Cryoglobulinemia Vasculitis Organization. May 24 ·. A Thanksgiving Story. Dr. Diane Dike lives with Cryoglobulinemia, a rare blood disorder that can be very painful, debilitating and life threatening. Seven years ago, when Diane's condition was greatly worsening, she was told about a doggie that had been in an accident and needed a new home Cryoglobulinemia is part of a group of diseases that cause damage and inflammation of the blood vessels throughout the body (vasculitis). There are three main types of this condition. They are grouped based on the type of antibody that is produced: Types II and III are also referred to as mixed cryoglobulinemia

Classic symptoms and signs of Buerger's Disease. The initial symptoms of Buerger's Disease often include claudication (pain induced by insufficient blood flow during exercise) in the feet and/or hands, or pain in these areas at rest. The pain typically begins in the extremities but may radiate to other (more central) parts of the body Mixed cryoglobulinemia can present as a small vessel vasculitis. Additional skin findings that may occur include livedo reticularis, urticarial papules, cold urticaria, Raynaud's syndrome, acrocyanosis, leg ulcers, and digital ulceration or gangrene. Hepatitis C is a frequent association Cryoglobulinemia is one of the most common symptoms of Hepatitis C and yet it is rarely discussed. Hep C Symptoms caused by Cryoglobulinemia include: Joint pain, aching muscles, shortness of breath, fatigue, spots or patches on the skin and skin ulcers or sores and also itchy skin. Click here to look at the graphics associated with Greg's blog Fig. 7.1 Skin histology. Cryoglobulinemic vasculitis with fibrinoid necrosis of the capillary walls with pyknotic nuclei and nuclear debris of granulocytes and mononuclear cell infiltrates Rheumatologic Manifestations. Arthralgias, usually bilateral and symmetric, are present in 40-90 % of patients. The clinical pattern may vary largely among patient series referred to different tertiary.

C. Greason A person's axons gradually die during axonal peripheral neuropathy. An axon, which can be 1 foot (30.5 cm) long, is the part of a nerve cell that extends from the neuron to target cells. In axonal peripheral neuropathy, a person's axons may gradually die.The result is pain, inability to control muscles, and a lack of sensation Leukocytoclastic vasculitis (LCV) refers to small blood vessel inflammation. It's also known as hypersensitivity vasculitis and hypersensitivity angiitis.. The word leukocytoclastic comes.

Cryoglobulinemia: Symptoms, Causes, Tests and Treatment

Less common clinical pictures of cryoglobulinemic vasculitis are represented by gastrointestinal (2-6%) and pulmonary (5%) involvement. Intestinal ischaemia may arise with acute abdominal pain; intestinal perforation is also described as well as symptoms that mimic cholecystitis and/or pancreatitis [ 38 ] Smith JB, Shenefelt PD, Soto O, Valeriano J. Pyoderma gangrenosum in a patient with cryoglobulinemia and hepatitis C successfully treated with interferon alfa. J Am Acad Dermatol 1996;34: 901-903. Small skin blood vessel occlusions by cryoglobulin aggregates in ulcerative lesions in IgM-IgG cryoglobulinemia. Berliner S, Weinberger A, Ben-Bassat M, Idesess C, Hazaz B, David M, Pinkhas J. The skin biopsy specimens from six patients with primary mixed IgM-IgG cryoglobulinemia were examined by immunofluorescence, light and electron microscopy

Pictures Other Plasma Cell Disorders. POEMS syndrome. Castleman's Disease. Cryoglobulinemia . MGUS. MGRS. Monoclonal Gammopathy Associated Neuropathy. Monoclonal Gammopathy Associated Glomerulonephritis . Back to Top. 5072846000 rajkumar.vincent@mayo.edu Mixed cryoglobulinemia syndrome (MCS) refers to the presence of either type II or type III cryoglobulins circulating in the serum, which can manifest clinically as a systemic vasculitis with manifestations ranging from purpura, arthralgia, and weakness to more severe neurologic and kidney involvement. The most common cause of MCS is hepatitis C. Mixed Cryoglobulinemia (MC) Overview Cryoglobulins are immunoglobulin (Ig) complexes that precipitate from the serum at low blood temperatures (<37°C) and then redissolve during incubation. 1 Cryoglobulinemia occurs when excess cryoglobulins circulate in serum, resulting in different clinical manifestations based on the immunologic composition of the cryoglobulins Score higher on exam day with Pixorize's visual mnemonics 1. COVID Arm. One of the most commonly reported side effects of the vaccine was a red, itchy rash at the injection site known as COVID arm or Moderna arm, as 95 percent of cases are.

Cryoglobulinemia - Vasculitis Foundatio

Cryoglobulinemia refers to a condition with circulating cryoglobulins in the serum. Cryoglobulinemia vasculitis refers to small to medium size vessel vasculitis resulting from the pathogenicity of cryoglobulin-containing immune complexes. The prevalence of clinically significant cryoglobulinemia is estimated at around 10 per million Cryoglobulinemia occurs when abnormal immunoglobulin proteins in the blood clump together when blood cools (for example, when it flows through the arms and legs).These abnormal proteins are called cryoglobulins. When cryoglobulins clump together in blood vessels, the vessels may leak, leading to bruises and reddish sores on the skin

How I treat cryoglobulinemia Blood American Society of

  1. Essential mixed cryoglobulinemia is often found in people who have a chronic (long-lasting) inflammatory condition, such as an autoimmune disease or hepatitis C. Most people with mixed cryoglobulinemia have a chronic hepatitis C infection. Cryoglobulins are antibodies. It is not yet known why they become solid or gel-like at low temperatures
  2. Cryoglobulin (% Cryocrit), Serum - The cryocrit is primarily intended for following a patient with previously defined and quantitated cryoglobulins. The cryocrit may consist of cryoglobulins, fibrin or mixtures of cryoglobulins and fibrin
  3. Adult non-Hodgkin's lymphoma (NHL) is a malignant cancer that begins in the lymph system. The lymph system is part of the body's immune system. Malignant means a disease spreads from where it starts and invades other areas of the body. Adult non-Hodgkin's lymphoma differs from lymphoma in children and has a different course of.
  4. Systemic disease affecting the blood vessels of the respiratory tract, kidneys, skin and sometimes of other organs as well. The process is characterized by necrotizing vasculitis with later formation of granulomas and ischemia of supplied tissues. Clinical signs: upper and lower respiratory pathways. glomelulonefritis
  5. Researchers found that volunteers lost an average of 14.67-28.5% of the fat in areas treated by cryolipolysis (as measured by calipers). When assessed with ultrasound, the fat loss was between 10.3% and 25.5%. A separate review of 16 studies on clinical efficacy, published in the Aesthetic Surgery Journal, found that subjects had an average.
  6. Cryoglobulinemia is one of the most common symptoms of Hepatitis C and yet it is rarely discussed. Apart from rashes and itchy skin other symptoms caused by Cryoglobulinemia include joint pain, aching muscles, shortness of breath, fatigue, spots or patches on the skin and skin ulcers or sores
  7. or. However it's important to note , like all aesthetic procedures, CoolSculpting can have side effects and rare risks of complication. Find out more about CoolSculpting side effects after the procedure, and frequently asked questions about CoolSculpting side effects

Eosinophilic granulomatosis with polyangiitis (EGPA) may manifest as as a painful, progressive skin rash, and be associated with secondary cryoglobulinemia — a condition where abnormal proteins in the blood clump together at low temperatures — a new case report shows.. While rare, it is critical that these conditions are recognized early to improve patient outcomes, according to the study. Cryoglobulinemia is a vasculitic disorder that mainly affects the small and, less frequently, medium-sized vessels. It is characterized by the occurrence of serum proteins that reversibly precipitate in vitro at temperatures < 37 °C and redissolve at body temperature The mixed cryoglobulinemia (MC) syndrome is a systemic inflammatory syndrome that causes small-to-medium vessel vasculitis due to cryoglobulin-containing immune complexes most commonly caused by chronic hepatitis C virus (HCV), and rarely by chronic hepatitis B virus (HBV). Its clinical presentation is significantly varied, with manifestations ranging from purpura, arthralgia, and myalgia to. What is Cryoglobulinemia? Cryoglobulins are proteins that are normally dissolved in blood, but become solid or gel-like at cold temperatures (less than 98.6° F). Cryoglobulinemia simply means that these abnormal proteins are in the blood. When these proteins are in their solid form they can physically block blood vessels throughout the body. They can also Continue Refers to the presence of cryoglobulins in the serum. Cryoglobulins are immunoglobulins that reversibly precipitate at temperatures below 98.6°F (37°C). Type I cryoglobulinemia is mostly associated with lymphoproliferative disorders (e.g., Waldenstrom macroglobulinemia); types II and III (mixed c..

Cryoglobulinemic vasculitis Genetic and Rare Diseases

  1. Cryoglobulinemia can cause vasculitis from blood vessel deposition of cryoglobulins.3 These proteins precipitate at temperatures below normal body temperature and can be associated with acral.
  2. Cryoglobulinemia may lead to purpuric or gangrenous lesions in the distal extremities, and its incidence is increasing recently because of its association with hepatitis C infection. Skin lesions.
  3. Chart and Diagram Slides for PowerPoint - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience
  4. Infections are other causes of vasculitis. An infection such as hepatitis C can cause cryoglobulinemia, which is a blood protein that turns to gel when the blood is exposed to temperatures below normal body temperature. Cryoglobulinemia leads to vasculitis in many cases
  5. (This is a retrospective study of nine children with pernio that demonstrated that laboratory abnormalities are more common among pediatric patients with pernio than in adults. Cryoglobulinemia and antinuclear antibodies were the most common findings occuring in four of nine and 2 of nine patients, respectively.) Weston, WL, Morelli, JG
  6. Cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud's disease, and open and/or infected wounds at or near the treatment site Potential Complications As with any surgical treatment that uses needle-based therapy and local anesthesia, there is a potential for site-specific reactions, including, but not limited to

Livedo reticularis is a lacy rash. The rash can appear in normal people or as part of disease. It is similar, but not identical to livedo racemosa. Other names for these phenomena are 'cutis marmorata', 'skin mottling' and 'marble skin'. This is because of the lacy, marbled appearance of pale and visible superficial blood vessels in. ioveraº allows health care providers to control pain by delivering precise, controlled doses of cold temperature to a targeted nerve The ioveraº technology represents a revolutionary cryotherapy platform The ioveraº system is a novel, FDA-approved non-opioid treatment that alleviates pain through a mechanism known as cryoanalgesia, which applies intensely focused cold therapy to a specific.

cryoglobulinemia photos on Flickr Flick

  1. Acknowledgments. The authors are indebted with Dr. Andrea De Marchi, San Giovanni Bosco Hospital of Turin, for providing the picture of cryoglobulinemic leukocytoclastic vasculitis, and Prof. Gianna Mazzucco, University of Turin, and Dr. Sanjeev Sethi, Mayo Clinic Institute, Rochester, for providing the pictures of renal histology
  2. with malignancy, cryoglobulinemia and systemic small-vessel vasculitis [5,7]. Role of tissue biopsy in the diagnosis of cutaneous LCV The main reason to perform a skin biopsy is to confirm that vasculitis and no other process is causing the cutaneous lesion in question. Several other questions can be answered by the ski
  3. Some 20 years later, Meltzer and Franklin provided a nosographical correlation of cryoglobulinemia with a particular clinical triad: purpura, arthralgias and asthenia. Cryoglobulinemia is a systemic vasculitis that mainly damages the small and medium‐calibre arteries and veins
  4. Hair Loss Photos, Alopecia and other Hair Diseases Herpes, HPV and other STDs Photos Light Diseases and Disorders of Pigmentation Lupus and other Connective Tissue diseases Melanoma (Skin Cancer), Nevi, and Moles: Nail Fungus and other Nail Disease Poison Ivy Photos and other Contact Dermatitis Psoriasis pictures, Lichen Planus and related disease

Cryoglobulinemia: Causes, symptoms, and treatmen

Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. Vasculitis is primarily caused by leukocyte migration and resultant damage. Although both occur in vasculitis, inflammation of veins or arteries on their own are separate entities Cryoglobulinemia (a condition where abnormal proteins in your blood thicken in cold temperatures) Cold urticaria (a skin condition that causes hives on your skin when it gets cold

Rheumatoid vasculitis (RV) is a rare but serious complication of rheumatoid arthritis (RA)—an inflammatory disease that causes severe joint pain and damage, and can move beyond the joints to other parts of the body. When RA affects the blood vessels, it is called rheumatoid vasculitis. RV causes inflammation and narrowing of the small- and. Cryoglobulinemia is part of a group of diseases that cause vasculitis -- damage and inflammation of the blood vessels throughout the body. The disorder is grouped into three main types, depending on the type of antibody that is produced: Cryoglobulinemia type I. Cryoglobulinemia typeII. Cryoglobulinemia type II Raynaud's phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. Spasms of blood vessels happen in response to cold, stress, or emotional upset. Secondary causes of Raynaud's include lupus, scleroderma, and other diseases Earlier this spring, before there was any real talk about skin manifestations of COVID, my partner called me in to see an unusual case. His patient was a healthy 20-year-old who had just come back. 10 Vasculitis Symptoms. Vasculitis includes a group of various uncommon diseases which are characterized by an inflammation of the blood vessels of the human body. This inflammation of the blood vessels causes alterations in their walls, scarring, weakening, narrowing and thickening of blood vessel walls. Vasculitis can be either acute or chronic

RheumaKnowledgy » Henoch-Schӧnlein Purpura

A review of the less frequent organ damage seen in the so-called essential mixed cryoglobulinemia, and distinguishing between cryodependent and cryofavouring organ involvement, is presented in this paper. In the first group, along with the well-known renal, cutaneous and articular lesions, the peripheral neuropathy and respiratory involvement. Cryoglobulinemia may be related to a variety of underlying systemic diseases. 1,3,4 Autoimmune and infectious diseases are typically associated with type II and type III cryoglobulinemia. 3,4 Type I cryoglobulinemia is usually associated with lymphoproliferative diseases, especially those that result in monoclonal gammopathies. 3 For.

Scleritis and Peripheral Ulcerative Keratitis WithPurpura | Musculoskeletal KeyVasculitisRaynaud Phenomenon - Dermatology - Medbullets Step 2/3Tocilizumab in the treatment of mixed connective tissueVasculitis at University of Massachusetts WorcesterSjögren’s Syndrome

Cryoglobulinemia . Cryoglobulinemia is an uncommon disease caused by an abnormal cluster of a kind of protein that blocks small blood vessels. It is most common in those with chronic hepatitis B and hepatitis C infections and can lead to circulation problems.  Raynaud Syndrome. Raynaud syndrome, a functional peripheral arterial disease, is a condition in which small arteries (arterioles), usually in the fingers or toes, narrow (constrict) more tightly than normal in response to exposure to cold. Constriction of small arteries causes fingers (or toes) to become pale or bluish, numb, and tingle Leukocytoclastic vasculitis (LCV) is a frequently-misused histopathologic term that describes the microscopic changes seen in various types of vasculitis affecting the skin and internal organs. However, LCV more typically refers to small-vessel vasculitis of the skin. The terms cutaneous LCV, cutaneous small-vessel vasculitis, and cutaneous. Numbness in lower legs may be accompanied by other symptoms such as pain, burning, and difficulty walking, and causes can be mechanical, metabolic, and inflammatory, amongst others. Read more below to learn 10 possible causes of numbness in lower legs, treatment, and more Vasculitis is an autoimmune disease that causes inflammation and narrowing of blood vessels (arteries, veins and capillaries). These vessels carry blood to and from the heart and the body's organs. In severe cases, the condition can cause organ damage or death. Types of vasculitis are grouped according to the size of the blood vessels affected